Genetic background of Brugada syndrome is more complex than what we would like it to be!
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چکیده
منابع مشابه
Genetic background of Brugada syndrome is more complex than what we would like it to be!
Brugada syndrome (BrS) has been named after the description of the disease made by the Brugada brothers in 1992. BrS is clinically characterized by arrhythmic events, in particular ventricular fibrillation, resulting in syncope and sudden cardiac arrest mainly in middle-aged men. The ECG shows a peculiar down-sloping elevation of the ST segment in the right pre-cordial ECG leads with inversion ...
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The Brugada syndrome (BrS) is an inherited arrhythmia characterized by ST-segment elevation in V1-V3 leads and negative T wave on standard ECG. BrS patients are at risk of sudden cardiac death (SCD) due to ventricular tachyarrhythmia. At least 17 genes have been proposed to be linked to BrS, although recent findings suggested a polygenic background. Mutations in SCN5A, the gene coding for the c...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2015
ISSN: 0008-6363,1755-3245
DOI: 10.1093/cvr/cvv135